Methylnaltrexone Pharmacokinetics in Neurointensive Care Patients
Status:
Completed
Trial end date:
2016-06-01
Target enrollment:
Participant gender:
Summary
- Assessment of pharmacokinetic parameters of once daily subcutaneously administered
methylnaltrexone in 10 evaluable neurointensive care patients.
- Quantification of methylnaltrexone passage through the blood-brain-barrier in critically
ill patients with severe cerebral affections.
- Observation of laxation response after methylnaltrexone application and relation to
plasma concentrations of methylnaltrexone.
- Assessing the safety of once daily administered methylnaltrexone in neurointensive care
patients.
- Trial with medicinal product