Septic shock is a subset of sepsis characterized by a decrease in vascular tone, which
contributes to impaired regional blood flow distribution, and leads to organic failure.
Besides intravenous fluids and adequate antimicrobial therapy, patients with septic shock
require vasopressor support, which can lead to many adverse effects, therefore,
non-vasopressor agents that can improve hemodynamic status are needed. In this randomized
controlled-study, the investigators will address the efficacy and safety of infusion with
methylene blue in patients with septic shock.