Methylene Blue Versus Vasopressin Analogue for Treatment of Septic Shock in Preterm Neonate

• Status: Unknown status
• Trial end date: 2020-02-19
• Target enrollment: 0
• Participant gender: All

Summary

A randomized, prospective study comparing methylene blue versus terlipressin in treatment of catecholamines resistant shock in preterm neonate

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Arginine Vasopressin; Methylene Blue; Terlipressin; Vasopressins

Criteria

Neonate with Gestational age at birth ≤ 36weeks

Inclusion Criteria:

• diagnosis of Septic shock according to clinical sepsis score of Tollner and Hematologic Scoring System of Rodwell

• Refractory septic shock defined as hypotension although adequate fluid resuscitate and high dose vasopressor(NE >0.5 mcg/kg/min)

• consent form

Exclusion Criteria:

• known case of G6pd deficiency

• Hx of drug allergy MB, NE, terlipressin

• Patients with severely impaired renal function.

• History of maternal drug intake of selective serotonin reuptake inhibitors,and Serotonin-Norepinephrine Reuptake Inhibitors