Methotrexate and Prednisolone Study in Erythema Nodosum Leprosum
Status:
Not yet recruiting
Trial end date:
2022-04-01
Target enrollment:
Participant gender:
Summary
Erythema Nodosum Leprosum (ENL) is a painful, debilitating complication of leprosy. Patients
often require high doses of corticosteroids for prolonged periods. Thalidomide is expensive
and not available in most countries. The use of corticosteroids for long periods is
associated with adverse effects and mortality. It is a priority to identify alternative
agents to treat ENL. Methotrexate (MTX) is a cheap, widely used medication which has been
reported to be effective in ENL resistant to steroids and thalidomide.
Phase:
N/A
Details
Lead Sponsor:
London School of Hygiene and Tropical Medicine
Collaborators:
Alert Hospital, Ethiopia Bombay Leprosy Project, India Dr. Soetomo General Hospital Leprosy Research Initiative Oswaldo Cruz Foundation The Leprosy Mission Bangladesh The Leprosy Mission Nepal The Leprosy Mission Trust, India