Methotrexate, Trimetrexate Glucuronate, and Leucovorin in Treating Patients With Refractory or Recurrent Osteosarcoma
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as methotrexate, trimetrexate glucuronate, and
leucovorin, work in different ways to stop the growth of tumor cells, either by killing the
cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy)
may kill more tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of trimetrexate
glucuronate when given together with methotrexate and leucovorin in treating patients with
refractory or recurrent osteosarcoma.