Method of Clopidogrel Pre-treatment Undergoing Conventional Coronary Angiogram in Angina Patients

• Status: Completed
• Trial end date: 2013-07-31
• Target enrollment: 0
• Participant gender: All

Summary

The study included 511 patients who underwent PCI because of angina during 2010-2011 at three Korean hospitals. Clopidogrel-naïve patients received either a loading dose (LD; 600 mg at 2-24 h before the procedure) or routine maintenance therapy (75 mg/day for ≥5 days) plus either a 300-mg reload (RL) or only the maintenance dose (MD).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Korea University Anam Hospital
• Treatments: Clopidogrel; Ticlopidine

Criteria

Inclusion Criteria:

• Written informed consent and, stable angina pectoris and, at least 1 ischemic evidence below

1. Treadmil test positive

2. ST-T change in resting ECG or 24-hour ECG

3. Regional wall motion abnormality in Echocardiography or cardiac MRI

4. Myocardial ischemia at MIBI scan

5. moderate to severe stenosis at coronary CT angiography

6. chest pain or dyspnea

Exclusion Criteria:

• AST or ALT > 3 times upper normal limits

• Serum creatinine > 2.0 mg/dL

• chronic malaborption status (disorder or operation)

• planned surgery within 1 year

• pregnancy or breast-feeding patients

• life expectancy < 1 year