Methadone in TKA for Post-op Pain and Opioid Reduction
Status:
NOT_YET_RECRUITING
Trial end date:
2026-12-15
Target enrollment:
Participant gender:
Summary
This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.