Methadone in Pediatric and Adult Sickle Cell Patients

• Status: Completed
• Trial end date: 2010-11-07
• Target enrollment: 0
• Participant gender: All

Summary

To determine the pharmacokinetics of methadone in children and adults with SCD who are experiencing a painful episode.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Washington University School of Medicine
• Treatments: Methadone; Morphine

Criteria

Inclusion Criteria:

• Greater than or equal to 7 years and less than or equal to 40 years

• Confirmed diagnosis of any form of sickle cell disease, including sickle cell anemia, sickle-hemoglobin C disease, and sickle-B thalassemia

• Currently experiencing a vaso-occlusive episode (VOE), defined as acute pain in the extremities

• Admitted to the inpatient unit for further treatment

• Started on morphine patient controlled analgesia and infusion for pain management

Exclusion Criteria:

• Diagnosis of acute chest syndrome

• New focal neurologic findings or clinical concern of stroke

• Aplastic crisis with hemoglobin 2 g/dl below steady-state value

• Allergy to morphine or methadone

• Any other medical condition that the attending physician deems to be a contraindication to therapy

• Liver or renal insufficiency or failure, and congestive heart failure