Overview

Methadone in Cystectomy Patients

Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
0
Participant gender:
All
Summary
The role of a single-dose intraoperative methadone on postoperative pain and opioid consumption in patients undergoing Surgeon Accuracy Robot Assistant cystectomy. A prospective double-blind, randomized controlled trial investigating the effect of a single-dose of intraoperative methadone in patients undergoing robotassisted cystectomy.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Aarhus
Treatments:
Methadone
Morphine
Criteria
Inclusion Criteria:

- All patients (≥18 years) scheduled for elective robot assisted cystectomy.

Exclusion Criteria:

- American Society of Anesthesiologists (ASA) physical status IV or V

- Prolonged QTc-interval assessed by electrocardiogram (> 440 milliseconds)

- Existing treatment with a high risk of QTc-interval prolongation

- Allergy to study drugs

- Preoperative daily use of opioids

- Inability to provide informed consent

- Severe respiratory insufficiency (oxygen treatment at home)

- Heart failure (ejection fraction < 30%)

- Acute abdominal pain

- Signs of severe liver dysfunction (cirrhosis, inflammation/hepatitis or liver
malignancy)

- Severe kidney insufficiency (estimated Glomerular Filtration Rate < 30 ml/min)

- Treatment with rifampicin

- Phaeochromocytoma

- Treatment with MAO-inhibitor during the last 14 days

- Pregnancy

- Nursing mothers

- Intraoperative conversion to open surgery (secondary inclusion criterion)

- Epidural analgesia in relation to surgical procedure