Methadone is an opioid that has been used for over 80 years to treat various types of pain,
including cancer pain. Despite its increasing popularity as a co-analgesic and first-line
treatment for cancer pain, there remain some outstanding questions regarding its use in
treating cancer pain, such as its efficacy compared to other opioids and its appropriateness
as a first-line treatment. We will conduct a Vanguard Randomized Clinical Trial (RCT) to
estimate the efficacy of methadone compared to morphine for the treatment of a newly defined
type of cancer pain, which we have termed 'adenocarcinopathic' pain (ACPP).