Methadone and Ketamine for Neuropathic Pain Treatment

• Status: Completed
• Trial end date: 2012-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Methadone and ketamine are effective for neuropathic pain management. However, the benefits of the association of both drugs are uncertain. Here, the investigators conducted a randomized, double-blind, in parallel, active controlled clinical trial to test the hypothesis that methadone combined ketamine (methadone/ketamine) is more effective than methadone or ketamine alone in reducing neuropathic pain.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universidade Federal de Santa Maria
• Collaborators: Hospital de Clinicas de Porto Alegre; Santa Casa de Misericórdia de Belo Horizonte
• Treatments: Ketamine; Methadone; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• patients complaining of pain for more than 6 months with neuropathic pain poorly responsive to drugs used to treat neuropathic pain (i.e. opioid, non-opioid, anticonvulsants, antidepressants), who were 22 to 77 years old

Exclusion Criteria:

• patients with a history of severe psychiatric disorder,

• misuse of illegal drugs or

• hepatic disease