Methadone Effects on Zidovudine (ZDV, AZT) Disposition
Status:
Completed
Trial end date:
1998-10-01
Target enrollment:
Participant gender:
Summary
To determine whether methadone maintenance alters the pharmacokinetics of zidovudine (AZT).
To determine whether any such effect of methadone on disposition of AZT is time dependent and
whether a metabolic interaction between AZT and methadone exists.
Injection drug users represent an increasing proportion of HIV-infected persons. Since daily
methadone maintenance is the major chemical treatment for injection drug abuse, it is
important to determine the impact of methadone on AZT absorption, distribution, and
elimination.
Phase:
Phase 1
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)