Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.

• Status: Completed
• Trial end date: 2016-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is being done to understand metformin's mechanisms of action regarding glucose production, protein metabolism, and mitochondrial function.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mayo Clinic
• Treatments: Glucagon; Lactulose; Metformin

Criteria

Inclusion Criteria:

• 35-65 years of age

• Fasting blood glucose >100 mg/dl

• BMI 27-36 kg/m2

• Waist Circumference: Men ≥ 104 cm; women ≥ 88 cm

• If previously on anti-diabetic medication, should be off for at least 1 month

Exclusion Criteria:

• Active use of hypoglycemic agents (< 1 month)

• Renal failure, creatinine ≥ 1.5 mg/dL in men or ≥ 1.4 mg/dL in women

• Alanine aminotransferase levels exceed 135 IU/L or aspartate aminotransferase levels exceed 129 IU/L (3 x the upper limit of normal)

• Congestive Heart Failure (EF < 40 %)

• Active coronary artery disease

• Recent (less than 6 weeks) or planned imaging study requiring IV contrast

• Participation in structured exercise (> 2 hr per week)

• Recent change in dietary habits or weight

• Tobacco use

• Use of systemic glucocorticoids

• Anti-coagulant therapy (warfarin/heparin)

• Pregnancy or breastfeeding

• Alcohol consumption greater than 2 drinks/day

• Uncontrolled Hypothyroidism, abnormal thyroid stimulating hormone levels

• Metformin Allergy