Metformin in Patients With Non-Alcoholic Fatty Liver Disease (NAFLD)

• Status: Unknown status
• Trial end date: 2005-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine the effect of metformin on biochemical and histological findings in NAFLD patients with insulin resistance syndrome.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kaplan Medical Center
• Treatments: Metformin

Criteria

Inclusion Criteria:

• ALT > 2 times normal range.

• Liver histology revealing non-alcoholic steatohepatitis [NASH] (type 2-4), without cirrhosis.

• Clinical characteristics of the metabolic syndrome as defined by the National Cholesterol Education Program (NCEP), but no overt diabetes.

• Negative work-up for other causes of liver diseases including alcohol intake < 40 g/week.

Exclusion Criteria:

• Diabetes mellitus.

• Alcohol intake > 40 g per week.