The study included 102 overweight type 2 diabetes mellitus patients with a body mass index
(BMI) of more than 25 in an open label study. They were advised intensive life style
modification which was reinforced at each follow-up visit. In addition they were prescribed
extended release metformin (XR) in a gradually increasing tolerable dose, starting with 0.5g
twice a day after meals. In addition, hypertension and dyslipidemia, when present, were
treated with appropriate recommended drugs. Those who completed a satisfactory regular
follow-up for at least 12 months or more were then analyzed for changes in their
anthropometric measurements and glycemic control.