This study aims to investigate the effect of metformin as host-directed therapy in
obese/overweight patients with dengue
Primary Objective
To evaluate the safety and tolerability of metformin in obese/overweight young adults and
children with dengue
Secondary Objectives
- To assess the effect of metformin therapy in obese/overweight patients with dengue on
physiological, clinical and virological parameters
- To assess the immunomodulation effects of metformin therapy in obese/overweight patients
with dengue
- To assess difference in gene expression between treatment group compared to
non-treatment population
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Oxford University Clinical Research Unit, Vietnam
Collaborator:
Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam