Metformin for the Treatment of Premature Pubarche in Girls
Status:
Terminated
Trial end date:
2014-04-01
Target enrollment:
Participant gender:
Summary
The primary objective of this study is to determine the safety and efficacy of metformin in
lowering serum DHEAS levels in girls with premature pubarche and secondary, to observe
changes in hormones associated with pubertal development including gonadotropins, sex
steroids, insulin, adipocytokines, and growth factors.