Metformin and Folate in Pregnant Polycystic Ovary Syndrome(PCOS) Women
Status:
Completed
Trial end date:
2011-05-01
Target enrollment:
Participant gender:
Summary
A more recent prospective nonrandomized placebo-controlled double-blind clinical study
demonstrated that metformin exerts a slight but significant deleterious effect on serum
homocysteine (Hcy) levels in patients with PCOS, and supplementation with folate is useful to
increase the beneficial effect of metformin on the vascular endothelium.