Metformin and Esomeprazole For Preterm Pre-eclampsia
Status:
Not yet recruiting
Trial end date:
2025-12-31
Target enrollment:
Participant gender:
Summary
A recent randomized controlled trial by Cluver et al included 180 women with preterm
pre-eclampsia between 26+0 to 31+6 weeks' gestation undergoing expectant management: 90 were
randomised to extended release metformin and 90 to placebo. Investigators found that extended
release metformin (3g daily) can prolong gestation in women with preterm pre-eclampsia.
Combination metformin and esomeprazole has shown promise in the treatment of preeclampsia as
both agents reduce placental and endothelial secretion of sFlt-1 and soluble endoglin, and
reduce endothelial dysfunction.