Metformin and Core Temperature in Obese and Lean Males

• Status: Completed
• Trial end date: 2016-06-01
• Target enrollment: 0
• Participant gender: Male

Summary

Metformin is known to increase 18F-FDG uptake in subjects using metformin in retrospective trials.

In this study the researchers aim to investigate the influence of metformin (500 mg 1/day) on temperature in the colon, glucose uptake in the colon and energy expenditure in healthy lean (BMI < 24kg/m2) or obese subjects (BMI>28kg/m2). The investigators will measure 18F-FDG uptake in the colon, temperature in the colon, insulin sensitivity and energy expenditure before after using metformin.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
• Treatments: Metformin

Criteria

Inclusion Criteria:

• Male

• Caucasian origin

• Subjects should be able and willing to give informed consent

• > 50 years old

• BMI< 24 kg/m2 or > 28 kg/m2

Exclusion Criteria:

• Renal failure (GFR< 60ml/min)

• Liver insufficiency (AST or alanine aminotransferase 3 times upper value)

• Chronic use of drugs or medication

• Diabetes mellitus

• Lactate acidosis or precoma diabeticum in medical history

• Acute or chronic diseases such as: dehydration, severe infection, shock, heartfailure, pulmonary insufficiency, recent heart attack

• Alcoholism