Metformin Therapy for Overweight Adolescents With Type 1 Diabetes
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
The objective of the proposed research is to evaluate the efficacy and safety of the use of
metformin in addition to standard insulin therapy in overweight and obese children and
adolescents, age 12-<20 years, with type 1 diabetes for at least 1 year. Secondary objectives
are to assess the effect of metformin on C-peptide levels, a measure of how much insulin is
still being produced by the beta cells of the pancreas, and on vascular dysfunction. In
addition, an ancillary study is planned to assess if metformin will improve tissue-specific
insulin resistance in type 1 diabetes using a hyperinsulinemic euglycemic clamp.