Overview

Metformin Plus Insulin on Non-obese Autoimmune Diabetes

Status:
Recruiting
Trial end date:
2021-04-01
Target enrollment:
0
Participant gender:
All
Summary
The objective of this study is to evaluate the therapeutic effect of metformin as additional treatment with insulin on non-obese autoimmune diabetes.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Second Xiangya Hospital of Central South University
Treatments:
Insulin
Insulin, Globin Zinc
Metformin
Criteria
Inclusion Criteria:

- Type 1 diabetes according to ADA criterias <5 years.

- Ageā‰„ 18 years and less than 70 years.

- Non-obese: defined as BMI less than 28 kg/m2

- Positive for at least one of the anti-islet autoantibodies: GADA, IA2A, ZnT8A

- Fasting or postprandial plasma C-peptide more than 100 pmol/L

- Written informed consent from the patient or family representative.

Exclusion Criteria:

- History of any malignancy or other severe diseases

- Female patients who are pregnant or breastfeeding before or during the three-year
follow-up

- Poor compliance or refusal to participate.