Metformin Pharmacokinetics in Patients With Chronic and Acute Heart Failure
Status:
Unknown status
Trial end date:
2018-04-30
Target enrollment:
Participant gender:
Summary
The study evaluates the pharmacokinetics of metformin in heart failure patients in acute and
chronic state in relation to metformin transporter genotypes. Participants have heart failure
and type 2 diabetes treated with metformin.
Hypothesis:
Primary: The renal clearance of metformin is decreased in acute state of congestive heart
failure compared with chronic state.
Secondary: Metformin trough values in HF patients are influenced by polymorphisms in
transporter genes relevant to the pharmacokinetics of metformin.