Metformin Induces a Dietary Restriction-like State in Human
Status:
Unknown status
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
The fact that metformin treatment has been associated with reduced risk of cancer and
cardiovascular disease raises the possibility of a beneficial role of metformin for other
age-related diseases. The actions of metformin resemble the effects of calorie restriction
(CR) to some extent, and microarray analyses have shown that metformin induces a gene
expression profile that aligns with that of CR in animal. The aim of the study is to
investigate whether metformin treatment can induce dietary restriction-like state in human.
Sixty overweight subjects will be included in this study, and participants will be divided 3
groups (20 cases in each group)including metformin group (0.85, twice daily), standard diet
group, and CR group. All subjects will be treated 6 months. At the end of this study, blood
samples and muscle samples will be obtained.