Overview

Metformin Hydrochloride in Treating Women With Stage I or Stage II Breast Cancer That Can Be Removed By Surgery

Status:
Terminated
Trial end date:
2011-07-01
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Metformin hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase I trial is studying how well metformin hydrochloride works in treating women with stage I or stage II breast cancer that can be removed by surgery.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Vanderbilt-Ingram Cancer Center
Collaborator:
National Cancer Institute (NCI)
Treatments:
Metformin
Criteria
Inclusion:

- Patients must provide informed written consent

- Eastern Cooperative Oncology Group performance status 0-1.

- Clinical stage I, II or IIIA invasive mammary carcinoma, any estrogen receptors(ER),
progesterone receptors (PR), or Human Epidermal Growth Factor Receptor (HER2/NEU)
status

- Patients who have measurable residual tumor at the primary site Measurable disease: a
mass that can be reproducibly measured by physical examination and/or ultrasound and
is at least 1 cm in size by physical examination or ultra-sound measurement

- Patients who will undergo surgical treatment with either segmental resection or total
mastectomy with lymph node evaluation

- Consultations: All patients should be evaluated by a surgeon prior to study entry.

- Available core biopsies from the time of diagnosis. These may include sections
paraffin-embedded material.

- Female subjects ≥18 years of age

- No prior chemotherapy for this primary breast cancer.

- Patients with a prior history of contralateral breast cancer are eligible if they have
no evidence of recurrence of their initial primary breast cancer.

- Women may have been taking tamoxifen or raloxifene as a preventive agent prior to
study entry but must have discontinued the drug for at least 21 days prior to study
enrollment.

- Patients must have adequate hepatic and renal function. All tests must be obtained
less than 4 weeks from study entry. This includes:

- Creatinine
- Bilirubin, SGOT, SGPT < or = to 1.5X upper limits of normal

- Able to swallow and retain oral medication

Exclusion:

- Patients with locally advanced disease who are candidates and wish to undergo
preoperative chemotherapy at the time of initial evaluation. Patients with operable
locally advanced disease (stage IIIA) are eligible for participation.

- Locally recurrent breast cancer

- Evidence of distant metastatic disease (i.e. lung, liver, bone, brain, etc.)

- History of diabetes mellitus

- Pregnant or lactating women

- Metformin treatment within 30 days of study entry

- Serious medical illness that in the judgment of the treating physician places the
patient at high risk of operative mortality.

- Malabsorption syndrome, disease significantly affecting gastrointestinal function, or
resection of the stomach or small bowel. Subjects with ulcerative colitis are also
excluded.

- History of other malignancy. Subjects who have been disease-free for 5 years, or
subjects with a history of completely resected non-melanoma skin cancer or
successfully treated in situ carcinomas are eligible

- Dementia, altered mental status, or any psychiatric condition that would prohibit the
understanding or rendering of informed consent.

- History of a medical condition leading to chronic hypoxemia and/or ischemia
(congestive heart failure, emphysema or chronic lung disease requiring supplemental
oxygen)

- Chronic metabolic acidosis (serum HCO3- < or = to 20 or requiring sodium bicarbonate
supplementation)

- Concurrent anti-cancer therapy (chemotherapy, radiotherapy, immunotherapy, hormonal
therapy, or any other biologic therapy)

- Concurrent treatment with an investigational agent

- Use of an investigational drug within 30 days or 5 half-lives, whichever is longer,
preceding the first dose of study drug.