Metformin+Cytarabine for the Treatment of Relapsed/Refractory AML
Status:
Terminated
Trial end date:
2016-01-21
Target enrollment:
Participant gender:
Summary
The purpose of the study is to determine if metformin in combination with cytarabine is safe
and effective. Participants in this research study have acute myeloid leukemia (AML) that has
come back after initial treatment or has not gone away with initial therapy.There is evidence
that metformin directly kills leukemia cells. Laboratory data have also shown that
combinations of metformin with cytarabine are more efficient than each agent alone in killing
leukemia cells in the laboratory.