Metabolism and Pharmacokinetics of Primaquine Enantiomers in Human Volunteers, Study 1

• Status: Completed
• Trial end date: 2018-03-01
• Target enrollment: 0
• Participant gender: All

Summary

To investigate the comparative tolerability, metabolism and pharmacokinetics of individual enantiomers of PQ in healthy human volunteers. The specific aim is the comparative evaluation of the metabolism, pharmacokinetic behavior, and tolerability of the isomers of PQ (RPQ and SPQ and the racemic mixture RSPQ) in normal healthy human volunteers.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Mississippi, Oxford
• Treatments: Primaquine

Criteria

Inclusion Criteria:

• Adults (18-60 years of age)

• Informed consent

• Healthy

Exclusion Criteria:

• Known history of liver, kidney or hematological disease;

• known history of cardiac disease, arrhythmia, QT prolongation;

• Autoimmune disorder;

• Report of an active infection;

• Evidence of G6PD deficiency