Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis.
Status:
Completed
Trial end date:
2019-08-27
Target enrollment:
Participant gender:
Summary
This study has been created to compare the addition of intravenous (IV) vitamin C, thiamine,
and hydrocortisone to the usual standard of care of sepsis and septic shock. Sepsis is a
possibly life-threatening condition in which a patient may have organ dysfunction due to an
infection. Septic shock is defined as low blood pressure and organ dysfunction that do not
improve after administering IV fluids. Standard of care for sepsis and septic shock include
early administration of IV antibiotics, IV fluids, and vasopressors if need be to provide
oxygen to vital organs.
A large amount of experimental data has shown that vitamin C and corticosteroids decrease the
release of inflammatory substances which may lead to organ failure seen in sepsis. Vitamin C
and corticosteroids also improve blood flow to vital organs and increase the body's ability
to respond well to vasopressor medications used in septic shock. Low blood levels of both
thiamine and vitamin C are common in sepsis. The study will be placebo controlled, meaning
one group will receive vitamin C, thiamine, and hydrocortisone, and the other will receive an
inactive substance ("placebo"). The goal of the study is to compare the effects of receiving
vitamin C, thiamine, and hydrocortisone (along with the standard sepsis care) versus placebo
and standard sepsis care.