Metabolic Effects of Subchronic Dopamine D2 Receptor Blockade by Antipsychotic Drugs in Healthy Humans
Status:
Completed
Trial end date:
2004-12-01
Target enrollment:
Participant gender:
Summary
We hypothesized that short-term treatment with AP drugs induces insulin resistance through a
mechanistic route that is independent of weight gain and that atypical drugs exert stronger
effects than typical compounds in this respect. We therefore treated healthy non-obese men
with olanzapine (atypical AP) or haloperidol (typical AP) for 8 days, and studied the impact
of these interventions on glucose and lipid metabolism by hyperinsulinemic euglycemic clamp,
isotope dilution technology and indirect calorimetry.