Metabolic Effects of Chemical Interactions in Toxicity
Status:
Completed
Trial end date:
2007-11-01
Target enrollment:
Participant gender:
Summary
This pilot study tests the feasibility of using GSH redox state and high resolution proton
NMR spectroscopy (1H-NMR) to detect metabolic changes due to acetominophen and sulfur amino
acid deficiency. Our central hypothesis is that the a 2-day sulfur amino acid deficiency will
alter acetominophen metabolism, acetominophen will affect sulfur amino acid homeostasis, and
the treatments together will alter the global metabolic profile, as measured by 1H-NMR
spectroscopy.
Phase:
N/A
Details
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)