Metabolic Consequences of Gastrointestinal Surgery
Status:
Terminated
Trial end date:
2019-03-11
Target enrollment:
Participant gender:
Summary
Surgery on the gastrointestinal (GI) tract results in profound changes to the metabolic
profile. This is well described, including the rapid resolution of diabetes seen after
bariatric surgery. The underlying pathophysiology, and incidence in lean patients undergoing
surgery for cancer, is somewhat less described. The investigators plan to assess the
symptomatic and glycaemic profile, as well as causative pathways, for metabolic symptoms in
patients after surgery on the GI tract. The investigators will use glucose tolerance tests,
physiological challenges with somatostatin analogues and antibiotics, and assess tissue
transcriptomic changes.
Phase:
N/A
Details
Lead Sponsor:
Cambridge University Hospitals NHS Foundation Trust