Overview

Metabolic Adaptation to High-frequent Hypoglycaemia in Type 1 Diabetes

Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
An experimental observational case-control study. The overall objective is to gain new knowledge about mechanisms involved in adaptation to recurrent hypoglycaemia in diabetes by investigating patients with type 1 diabetes and healthy controls. The knowledge to be obtained may feed into experimental hypoglycaemic clamp studies to further elucidate the effect of the adaptations during acute hypoglycaemia. Ultimately, it may lead to intervention studies aiming at the maintenance of functional capability during hypoglycaemia in patients with type 1 diabetes to reduce their risk of severe hypoglycaemia.
Phase:
N/A
Details
Lead Sponsor:
Nordsjaellands Hospital
Collaborators:
Danish Research Centre for Magnetic Resonance
Steno Diabetes Center Copenhagen
University of Copenhagen
Treatments:
Epinephrine
Glucagon
Insulin
Insulin, Globin Zinc