Acidosis (accumulation of acid in the body) may be an underrecognized problem in patients
after renal transplantation. It may have consequences on physical performance due to negative
effects on bone and muscle metabolism.
Therefore, the purpose of this study is
1. to determine the status of physical capacity and bone structure in renal transplant
patients with metabolic acidosis
2. to study the effect of substituting base equivalents (citrate) on acid/base status of
renal transplant patients with acidosis
3. to compare the status of physical capacity and bone structure in renal transplant
patients with metabolic acidosis before and after substitution with citrate
Phase:
Phase 2
Details
Lead Sponsor:
University of Zurich
Collaborators:
Swiss Federal Institute of Technology University of Texas Southwestern Medical Center