Topical photodynamic therapy (PDT) is widely used to treat superficial non-melanoma skin
cancer (NMSC) and dysplasia, notably actinic keratosis and may also be effective in a range
of other dermatological conditions. A major limitation of PDT is pain during irradiation. A
lack of knowledge of the mechanism of PDT-induced pain has limited the development of
effective approaches for prevention or relief of this adverse effect. The investigators have
investigated the possible efficacy of menthol for PDT pain ex vivo and will now study this in
a clinical trial. This proposal describes the prospective randomised double blind, placebo
controlled clinical trial that will be undertaken to investigate the use of topical menthol
for PDT-induced pain relief in patients with actinic keratosis of the face and scalp who will
be attending general dermatology and PDT outpatient clinics at Ninewells Hospital, Dundee.