Overview

Memory Modulation by Pain During Anesthesia

Status:
Completed
Trial end date:
2018-12-12
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to determine the effects of pain on facilitating long-term auditory memory in the presence and absence of distinct intravenous anesthetics. The ability to identify previously presented words from a list assessed the degree of memory formation. In a subset of subjects, functional magnetic resonance imaging was used to identify the neural correlates of memory inhibition or facilitation by the combination of pain and anesthetic used.
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
University of Pittsburgh
Collaborator:
Foundation for Anesthesia Education and Research
Treatments:
Dexmedetomidine
Ketamine
Midazolam
Criteria
Inclusion Criteria:

- Healthy adult volunteers, with normal memory and hearing, whose native language is
English

Exclusion Criteria:

- pregnancy

- significant memory or hearing loss

- sleep apnea

- chronic pain

- metal or electronic implants

- claustrophobia

- Currently taking: antidepressants, anti-psychotics, antihistamines, anti-anxiety
medication, stimulants, sleep-aids, or pain medication