Memory Enhancement by Gamma-hydroxybutyrate vs. Trazodone in Major Depressive Disorder.
Status:
Recruiting
Trial end date:
2022-03-31
Target enrollment:
Participant gender:
Summary
30 healthy adults and 30 patients with major depressive disorder, will take part in three
single-application pharmacological interventions (GHB vs. Trazodone vs. placebo p.o.) to test
potential effects of these drugs on nocturnal memory consolidation. All participants will be
assessed with mood state questionnaires, tests of emotional, procedural and declarative
memory consolidation, polysomnography, EEG and neuroinflammatory biomarkers. At experimental
nights, learning tasks are performed prior to sleep. The next morning, recalling tasks are
performed. Each subject will pass through 5 study nights (1 screening, 1 adaptation and 3
experimental nights).