Participants (n=20) will be identified at routine care visits performed at the Rochester
Multiple Sclerosis Center. Eligible participants will have MS by McDonald Criteria,7 and will
have a modified Ashworth spasticity rating8 of two or higher in at least one lower extremity
muscle group. Participants will be seen at screening, one, and three months, and will be
evaluated using the modified Ashworth scale,8 pendulum test,9 toe tapping test,10 manual
muscle testing,11 timed 25 foot walk,12 and Multiple Sclerosis Functional Composite.13 The
type and severity of any adverse events will be recorded using standard definitions.
Participants will be instructed to call between visits to inform the investigators regarding
any adverse events they experience. Follow-up will continue until all adverse events resolve
or stabilize.