Memantine Treatment of Compulsive Buying

• Status: Completed
• Trial end date: 2010-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This is an 8-week, open-labe study of memantine in the treatment of compulsive buying.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Minnesota; University of Minnesota - Clinical and Translational Science Institute
• Treatments: Memantine

Criteria

Inclusion Criteria:

1. men and women age 18-65

2. current CB using the clinician-administered Structured Clinical Interview for Compulsive buying (SCI-CB)

3. buying behavior within 2 weeks prior to enrollment

Exclusion Criteria:

1. infrequent buying (i.e. less than one time per week) that does not meet proposed criteria for CB

2. unstable medical illness or clinically significant abnormalities on laboratory tests or physical examination at screen

3. history of seizures

4. myocardial infarction within 6 months

5. current pregnancy or lactation, or inadequate contraception in women of childbearing potential

6. a need for medication other than memantine with possible psychotropic effects or unfavorable interactions;

7. clinically significant suicidality;

8. current Axis I disorder determined by the SCID and SCID-compatible modules for impulse control disorders, except for nicotine dependence

9. lifetime history of bipolar disorder type I or II, dementia, schizophrenia, or any psychotic disorder determined by SCID

10. current or recent (past 3 months) DSM-IV substance abuse or dependence;

11. positive urine drug screen at screening

12. initiation of psychotherapy or behavior therapy within 3 months prior to study baseline

13. previous treatment with memantine

14. treatment with investigational medication or depot neuroleptics within 3 months, with fluoxetine within 6 weeks, or with other psychotropics within 2 weeks prior to study baseline