Memantine Treatment for Improving Rehabilitation Outcomes and Preventing Depression in Older Adults

• Status: Completed
• Trial end date: 2009-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will evaluate the effectiveness of memantine in improving rehabilitation outcomes and preventing major depressive disorder in older adults who have been admitted to a rehabilitation hospital for a hip fracture or cardiopulmonary condition.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Eric Lenze; University of Pittsburgh
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Memantine

Criteria

Inclusion Criteria:

• Admission to a skilled nursing facility for rehabilitation within 3 months of recent disabling medical event (e.g., hip fracture)

• Medically stable (e.g., no active seizures, delirium, unstable pulse/blood pressure)

Exclusion Criteria:

• Aphasia or cognitive impairments sufficiently severe to prevent valid assessment (e.g., a score of less than 22 on the Mini Mental State Examination)

• Current major depressive episode

• History of or current psychosis or mania

• Current substance or alcohol abuse or dependence (within 3 months of study entry)

• Current use of memantine

• Sensitivity or contraindication to memantine

• End-stage kidney, liver, heart, or lung disease

• Recent hemorrhagic stroke

• A FIM score of greater than 70 (on a 91 point scale)