Melphalan With BBBD in Treating Patients With Brain Malignancies
Status:
Terminated
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as melphalan, work in different ways to stop the
growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving
drugs directly into the arteries around the tumor may kill more tumor cells. Mannitol may
open the blood vessels around the brain [Blood-Brain Barrier Disruption (BBBD)]and allow
melphalan to be carried directly to the brain tumor. Giving melphalan together with BBBD may
be an effective treatment for central nervous system cancer.
PURPOSE: This phase I trial is studying side effects and best dose of melphalan when given
together with mannitol in treating patients with central nervous system cancer.