Overview

Melatonin for Prevention of Radiation Induced Oral Mucositis

Status:
Completed
Trial end date:
2018-12-01
Target enrollment:
0
Participant gender:
All
Summary
The main aim of this study was to evaluate the effectiveness of melatonin in prevention of radiation induced oral mucositis clinically and biochemically.
Phase:
Phase 2
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Hams Hamed Abdelrahman
Collaborators:
Alexandria University
Faculty of Dentistry, Alexandria University
Treatments:
Melatonin
Criteria
Inclusion Criteria:

- Patients who are going to receive radiotherapy as a treatment of head and neck cancer
either as postoperative (adjuvant) therapy or definitive therapy.

- Patients whose radiotherapy treatment planned dose is between 60-70 Gy.

- Patients who had received chemotherapy prior to radiotherapy or are going to receive
chemotherapy in concomitant to radiotherapy.

Exclusion Criteria:

- Patients under Anticoagulants such as warfarin, heparin, or aspirin.

- Patients under Fluvoxamine (Luvox) and Nifedipine medications.

- Patients whose radiotherapy treatment planned dose is lower than 60 Gy.

- Pregnant and lactating women.

- Patients suffering from any uncontrolled systemic diseases (such as diabetes,
cardiovascular, liver disorder, renal dysfunction)

- Patients with findings of any physical or mental abnormality which would interfere
with or be affected by the study procedure.