Melatonin and Cardiac Outcome After Major Surgery

• Status: Completed
• Trial end date: 2008-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess whether treatment with melatonin can reduce cell damage and inflammatory stress response and thereby occurrence of myocardial injury after abdominal aortic surgery.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Gentofte, Copenhagen
• Treatments: Melatonin

Criteria

Inclusion Criteria:

• Indication for elective abdominal aortic aneurism surgery or periphery atheroscleroses with indicated protheses operation

• Patients between 18 and 80 years old

Exclusion Criteria:

• Patients with ASA class > 3

• Anticoagulation therapy (marevan and marcoumar)

• Preoperative therapy with opioid, anxiolytic and hypnotic medication

• Renal insufficient (preoperative creatinin > 200 mmol/l)

• Well-known liver insufficient

• Alcohol consumption (more than 5 drinks)

• Compliance (language difficulty, mental problems etc.)

• Pregnancy and breast-feeding

• Lack of written consent