Overview

Medroxyprogesterone Acetate With or Without Entinostat Before Surgery in Treating Patients With Endometrioid Endometrial Cancer

Status:
Completed
Trial end date:
2020-03-12
Target enrollment:
0
Participant gender:
Female
Summary
This randomized surgical window trial evaluates the effect of adding entinostat to medroxyprogesterone acetate before surgery works on progesterone receptors on endometrioid endometrial tumors. Medroxyprogesterone acetate is a progesterone, a hormone produced by body normally. Entinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving medroxyprogesterone acetate with or without entinostat may effect tumors from endometrioid endometrial cancer.
Phase:
Early Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
National Cancer Institute (NCI)
Collaborator:
NRG Oncology
Treatments:
Entinostat
Histone Deacetylase Inhibitors
Medroxyprogesterone
Medroxyprogesterone Acetate
Criteria
Inclusion Criteria:

- Patients must have a histologically proven diagnosis of endometrioid endometrial
adenocarcinoma by endometrial curettage or biopsy within 8 weeks prior to
registration; central pathology review will be required as part of the study but not
for registration purposes

- History/physical examination within 42 +/- 5 days of planned surgical procedure (18-21
days from day 1); further protocol-specific assessments

- The trial is open only to women with primary endometrioid adenocarcinoma of the
uterine corpus (all histologic grades and stages) who are planned and appropriate for
primary surgical treatment to include removal of the uterine corpus via any surgical
modality; the patient must be considered a suitable surgical candidate

- Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of
0, 1, 2, or 3 within 28 days prior to registration

- Formalin-fixed, paraffin-embedded tumor tissue from the biopsy or curettage must be
submitted along with the corresponding pathology report

- Platelets >= 100,000/ul

- Granulocytes (ANC) >= 1,500/ul

- Creatinine =< 1.6 mg/dl

- Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 3 x
upper limits of normal

- Bilirubin within institutional normal limits

- The patient must provide study-specific informed consent and authorization permitting
release of personal health information prior to study entry

- Any patients of childbearing potential must have a negative pregnancy test

Exclusion Criteria:

- Patients with any non-endometrioid histology (such as serous, clear cell, or
carcinosarcoma)

- Patients who have received prior progestin or anti-estrogen therapy during the 3
months before the diagnosis of endometrioid adenocarcinoma of the uterine corpus is
established; estrogen therapy alone is allowed

- Patients with ECOG performance grade of 4

- Patients with history of thrombophlebitis within the past 2 years or ongoing
thromboembolic disorders

- Patients who have previously received systemic, radiation or other treatment for
uterine cancer

- Patients for whom formalin-fixed, paraffin-embedded tumor tissue from the biopsy or
curettage is unavailable

- Patients must not have previously received a non Food and Drug Administration (FDA)
approved histone deacetylase (HDAC) inhibitor in a clinical trial setting (entinostat,
belinostat)

- Patients must not be currently taking or have ever taken vorinostat (Zolinza, Merck),
panobinostat (Farydak, Novartis) or romidepsin (Istodax, Gloucester Pharmaceuticals)