Medication Effects on Periurethral Sensation,Urethral Sphincter Activity and Pressure Flow Parameters
Status:
Completed
Trial end date:
2011-04-01
Target enrollment:
Participant gender:
Summary
Lower urinary tract symptoms such as urinary leakage and overactive bladder affect millions
of American women. Women may develop these problems because the innervation of the muscles of
the bladder and urethra are injured. Most research on treating these problems has focused on
the abnormalities of the bladder muscle, but newer studies have shown abnormalities in the
innervation and muscle function of the urethra.
Women with these symptoms may benefit from treatment with medications to improve their
urethral function. However, to truly understand what types of medications will help women
with these symptoms, the investigators wish to study how these medications affect innervation
and muscle function in healthy women who do not have lower urinary tract symptoms.