Medical Management of Late Intrauterine Death.

• Status: Completed
• Trial end date: 2014-05-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to assess the therapeutic efficacy and safety of isosorbide dinitrate-oxytocin in combination in the management of late intrauterine foetal death.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of Perinatology
• Collaborator: National Council of Science and Technology, Mexico
• Treatments: Isosorbide; Isosorbide Dinitrate; Isosorbide-5-mononitrate; Misoprostol; Oxytocin; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Closed cervix without evidence of cervical dilation or baseline uterine activity.

• A Bishop score of <5, having intact membranes.

• Gestation greater than or equal to 20 weeks established by the date of menstruation or by fetometry and ultrasound-confirmed late IUFD.

Exclusion Criteria:

• Multiple pregnancies.

• IUFD after late foeticide or the management of specific medical conditions associated with an increase in the risk of IUFD.

• Patients with a history of hypertension.

• Women with a history of unexplained antepartum haemorrhage, pelvic dystocia or any another counter-indications where medications were used.