Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics
Status:
Completed
Trial end date:
2020-01-08
Target enrollment:
Participant gender:
Summary
The focus of the study is to better understand the mechanisms causing antibiotic-associated
diarrhea (AAD) and how probiotics may prevent some of the iatrogenic effects of antibiotic
medications. One of the most common indications for probiotics is for prevention of
antibiotic-associated diarrhea. Clinically, different probiotic strains have demonstrated the
ability to prevent AAD; however, the mechanism of action behind this effect has not been
elucidated. Data from several studies suggest that antibiotic-induced disruption of commensal
bacteria in the colon results in a significant (up to 50%) reduction in short chain fatty
acid (SCFA) production and a concomitant reduction in Na-dependent fluid absorption resulting
in AAD. Probiotics have been shown to ameliorate a variety of gastrointestinal disease states
and thus, the study investigators hypothesize that administration of a probiotic yogurt will
protect against the development of AAD.
Phase:
Early Phase 1
Details
Lead Sponsor:
Georgetown University
Collaborators:
National Center for Complementary and Integrative Health (NCCIH) University of Maryland University of Maryland, Baltimore