The Objectives of the study are to: (1)compare the inflammatory response and insulin
resistance in skeletal muscles during a systemic infusion of lipid with that during a local
infusion of lipid into the femoral artery. which would cause minimal or no systemic
hyperlipidemia but local plasma free fatty acid (FFA) concentrations similar to those during
the systemic lipid infusion, and (2) determine the inflammatory response and insulin
resistance in skeletal muscle during an infusion of lipid into the femoral artery as
described above after NF-KB inhibition by high dose salicylate treatment in humans.
Details
Lead Sponsor:
US Department of Veterans Affairs VA Office of Research and Development