Mechanisms of Insulin Resistance in Critical Illness: Role of Systemic Inflammation and GLP-1

• Status: Completed
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to determine the role of inflammation and the insulin regulating hormone GLP-1 during critical illness.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Rigshospitalet, Denmark
• Collaborators: Novo Nordisk A/S; University of Copenhagen
• Treatments: Glucagon; Glucagon-Like Peptide 1

Criteria

Inclusion Criteria healthy subjects:

• Healthy (assessed by medical history and clinical examination)

• Age 18-40years

• BMI < 30kg/m2

Exclusion Criteria healthy subjects:

• Previous resection of the small intestine (not including the appendix)

• presence of any inflammatory illness during the fortnight preceding the study

Inclusion Criteria critically ill patients:

• Age>18 years

• HbA1C<6,5%

• Admission to the ICU within the last 72 hours