Mechanisms of Glucose Lowering Effect of Colesevelam HCl
Status:
Completed
Trial end date:
2009-04-01
Target enrollment:
Participant gender:
Summary
The mechanism by which colesevelam HCl lowers glucose is not known. Knowledge of the
potential mechanism of action is important for defining the role of the drug among oral
antidiabetic agents available for use in subjects with diabetes. The objective of this study
is to provide insight into the mechanisms of action of colesevelam HCl in T2DM. The
mechanisms of interest include hepatic insulin sensitivity, rate of appearance of exogenous
glucose and changes in incretin hormone concentrations.