Overview

Mechanisms Underlying Metabolic Syndrome in Obesity

Status:
Completed
Trial end date:
2011-01-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to better understand the link between obesity and diabetes or pre-diabetes.
Phase:
Phase 4
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Philip Kern
University of Arkansas
Collaborators:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institutes of Health (NIH)
Treatments:
Pioglitazone
Criteria
Inclusion Criteria:

- 18-65 years of age

- BMI 28+

- diabetes, impaired glucose tolerance or normal glucose tolerance

Exclusion Criteria:

- AST >2x normal

- congestive heart failure

- history of coronary artery disease

- chronic renal insufficiency (creatinine > 1.4mg/dl)

- use of gemfibrozil, ACE inhibitors, and angiotensin receptor II blockers, or
anticoagulants